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Home / Campus Directory / James Lissemore

James Lissemore, PhD

Professor - Biology

James Lissemore, PhD Profile Picture

eMail

jlissemore@jcu.edu

Phone Number

216-397-4196

Location

Dolan Science Center W241

James Lissemore, PhD Profile Picture

Professor

Expertise: Molecular genetics, Genetics

Research Interests

My research focuses on genetic and molecular analysis of germline stem cells in the model organism C. elegans, a soil nematode. All multicellular organisms have stem cells which have the capacity both for becoming different types of cells (differentiation) and for retaining their identity as stem cells (self-renewal). Germline cells, the cells that give rise to gametes in animals, are stem cells. Some germline cells divide and remain as stem cells while other germline cells divide and commit to becoming gametes, i.e. eggs and sperm. My lab is currently focused on identifying and understanding genes required for germline stem cells to function properly.

 

Recent Courses

BL 1500 – Principles of Biology I BL 2130 – Genetics BL 2150/2155 – Introduction to Biotechnology Lab BL 2600 – Social Inequality and Disease BL 4650 – Molecular Genetics BL 4810 – Biology Seminar

 

Selected Publications

Stein, S., Zucaro, O., Smith, H., O’Connell, K., Spoerke, J. Maine, E.M., and Lissemore, J.L. 2022. om92, a glp-1 enhancer mutation, is an allele of ekl-1. microPublication Biology 10.17912/micropub.biology.000698.

Lissemore, J.L., Connors, E., Liu, Y., Qiao, L., Yang, B., Edgley, M.L., Flibotte, S., Taylor, J., Au, V., Moerman, D.G., and Maine, E.M. 2018.  The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans. G3 (Genes, Genomes, Genetics) 8: 1535–1544.

Lissemore, J.L., Bayes, J., Calvey, M., Reineke, L., Colagiavanni, A., Tscheiner, M., and Mascotti, D.P. 2009. Green fluorescent protein is superior to blue fluorescent protein as a quantitative reporter of promoter activity in E. coli. Mol. Biol. Rep. 36:1107-12.

Lissemore, J.L., Lackner, L.L., Fedoriw, G.D., and De Stasio, E.A. 2005. Isolation of C. elegans genomic DNA and detection of deletions in the unc-93 gene using PCR.  Biochem. Mol. Biol. Educ., 33:219-226.

Degrees

B.A. in Microbiology, Rutgers University Ph.D. in Molecular Biology, University of Wisconsin, Madison Post-doctoral research in cloning and regulation of glycolytic enzyme genes in D. melanogaster, Syracuse University Post-doctoral research in genetic and molecular analysis of germline development in C. elegans, Syracuse University